Im not sure if it is an upstream issue. Anyway, I open a gnome-terminal (it doesnt matter what app I use, but I use gnome-terminal because the cursor changes). I put the mouse focus over the gnome-terminal, then I change to another virtual desktop (ctrl + alt + down), if here isnt any app in this new virtual desktop, the mouse cursor is in the text shape yet and It does nothing when I press mouse button, neither left, right or middle button work anymore.

However when I change to shell overview (with the windows key or taking the cursor at botton left corner) the mouse begin to work again.